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Doctors' Answers to "Frequently Asked Questions" - Trilafon


These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

General Information
Question: I am a doctor with a psychotic chronic,presently not acute patient on trilafon low dose now who was also on a tca (now dced). Ekg had shown a conduction defect which I cant exactly recall . Anyhow,the Ekg reader threw the PDR in comment noting danger of its use. So,I asked for medical comment on alternate Rx and got comment that I was the psychiatrist. He also didnt accept my DCof sinequan for Zoloft. I forced the issue for him to set a cardiac/ekg protocol. It should be noted that the patient had no cardiac symptoms other than for the ekg findings which had shown no change. Trilafon is now only at two mgm/day and voices are minimal with it. He is now not on any antidepressant for the zoloft was giving him an inner restlessness at 50mgm only -at the time the other MD had no knowledge of this and was only responding to the ekg finding. Anyhow, I am pursuing with the low dose trilafon and he may need more, but I intend to repeat Ekgs.Patient is male in late 20-30+ yrs. Any comment on use of this grouping of antispychotic Rx., Thanks

Answer: Fire your consultant. Sounds like their is probably no current contraindication to the tricyclics. The ekg problems are usually dose dependent and you don't mention his dosage. High doses could be a problem," average" doses are probably ok unless he has a documented problem with arrthymias.

General Information
Question: I visited your web site on 9/2 and was unable to find information on Trilafon, please share any information you may have.

Answer: Trilafon is the brand name for perphenazine. This is a drug which is used to treat different types of psychotic behavior. It is believed to work in the central thalamus or hypothalamus. It is a effective drug; but, like many of this class can produce tardive dyskinesia over time. This is a syndrome of uncontrollable grimaces and tics of the facial muscles. Once present, it will not abate and is currently untreatable. Occasional cases of neuroleptic malignant syndrome are also seen. This results in sustained rise in temperature, muscle rigidity and cardiac arrhythmiaís.


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