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Doctors' Answers to "Frequently Asked Questions" - Tocopherol
Answer: There is not an established toxic level of Vitamin E. This is peculiar since all the other fat soluble vitamins A, D, K can be very toxic in high doses. We know that Vitamin E will decrease vascular disease(studies in progress, but most studies show a benefit). It appears that 150 to 200 units a day is the minimum dose necessary to get improvement. However, we do not know the optimum dose and we also do not know if high doses are more beneficial or less so than lower doses. I usually recommend 400 units or so a day until further research is forthcoming.