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Doctors' Answers to "Frequently Asked Questions" - Spironolactone
What is Spironolactone and Possible Side Effects [posted 11/3/98]
Answer: Spironolactone has a structure similar to estrogen and can cause breast enlargement. This is the contraindication in men, although not all men develop the problem. As to the tumors, I have not seen this problem with patients and the drug has been around 30 years or so. I suspect that we would have seen a human problem if one existed.