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Doctors' Answers to "Frequently Asked Questions" - Seldane
Seldane-D Substitute [posted 8/14/98]
Answer: Allegra is the metabolically active part of Seldane and comes in an Allegra-D format as well. I'd try this first.
Answer: Didn't used to think so, but recent information shows a major change in many drugs while taking grapefruit juice, particularly some calcium channel blockers. However, Seldane is no longer available so this is probably a mute point.
Seldane Prescription Instructions
Answer: Seldane is getting ready to be pulled from the market. I would use Claritin or Allegra in place of Seldane.
Answer: Side effects include Ventricular Tachycardia, Ventricular Fibrillation, Cardiac arrest, low blood pressure, palpitations, syncope, dizziness, drowsiness, headache, fatigue, nervousness, weakness, increase appetite, nausea, vomiting , change in bowel habits and dry mouth. Interactions with other drugs include Itraconazole, Ketoconazole, Erythromycin, Clarithromycin and Azithromycin. Any of these drugs are given with Seldane can cause serious cardiovascular side effects.
Answer: Seldane and Seldane-D will soon be off the market. This is due to buildup of the drug
when taken with certain other drugs, especially macrolides (erythromycin, Biaxin, Zithromax,
etc.) and/or ketoconazole (an anti-fungal drug). This drug is relatively non-sedating compared
to traditional antihistamines like Benadryl, etc. Consequently was used a lot for allergic
symptoms. Other drugs that act in a similar manner, but don't have the interaction with the
above drugs, are Claritin, Claritin-D, Allegra, etc. Afrin is mainly pseudo-effedrine (similar to
the D part of Seldane-D or Claritin-D). You shouldn't use this more than one or two days in
a row or you can develop the exact runny nose you are trying to avoid. This is called rhinitis
medicosium. Other drugs (not antihistamines) that work on allergic symptoms are nasal steroid
inhalers and cromlyn sulfate nasal inhalers. These will not help the itching eyes, ears, etc.,
but will generally help allergic rhinitis.