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Doctors' Answers to "Frequently Asked Questions" - Prempro
Answer: Probably not assuming you are post menopausal.
Answer: There are some soy and yam based products that have some estrogen like activity. Check with your pharmacist for brand names.
Answer: Prempro is a combination of estrogen and progesterone. Premarin is only estrogen. The reason to combine progesterone with estrogen is to minimize the risk of uterine cancer by giving monthly periods(caused by the progesterone effect). Since your wife doesn't have a uterus, the progesterone is pointless. However, there are some who believe that combining estrogen with progesterone will lower the risk of cancer of the breast. Most physicians would give only the premarin or equivalent-that would be my option if she were my patient.
Prempro [posted 1/13/99]
Answer: Sounds like you need to get a "heavy" period and completely slough the lining of your uterus. This usually fixes the problem. By the way, osteomalacia is a completely different problem from osteoporosis and would entail Vitamin D enhancement.
Prempro & Cancer Concerns [posted
Answer: There is an increased risk;but, it is not high. It took combining 8 different studies, over 20-30,000 women, before the risk was identified. If the risk was high, one study would have showed the correlation(like the early smoking/cancer studies). If you have a family history of breast cancer(the risk rises with number, early age and closeness of relationship) you should probably not use estrogen. Reloxifene is probably a good alternative for these women. If you do not have breast cancer in the family, your major risk is cardiovascular. Estrogen is one of the few drugs that will reduce cardiovascular risk.(We think reloxifine will, but, not proven like estrogen). However, estrogen use is an individual decision. If you are not going to use it, consider reloxifene and you will need treatment for osteoporosis(or at least aggressive monitoring).
Prempro Side Effects [posted
Answer: A salty taste usually indicates gastric reflux, as to the dryer mouth-not clear. I suspect if you had the problem immediately after starting Prempro it could be the culprit. But, wouldn't expect it to be the cause if you have been on it 6 months.
Prempro Alternatives [posted
Answer: About 20-30% of women experience mood changes on birth control pills or estrogen replacement. Sometimes it is related to the progesterone only. Sometimes to both the estrogen and progesterone, sometimes to the relative strengths. Discuss with the md who put you on Prempro. Reloxifine may be an alternative.
Vision Changes with Prempro
Answer: Certainly sounds reasonable;but, not a common problem.
Prempro [posted 8/13/98]
Answer: This is a usual problem with all the steroid replacement regimes. This does not mean that the dosage is excessive, merely your reaction to the medication. It may limit your ability to take the drug, but is common.
Prempro [posted 8/7/98]
Answer: Sounds like you were fairly progesterone deficient and the progesterone sloughed a built up endometrium. As to whether you will continue to have bleeding is another story. I would guess that you need a large dose of progesterone to start with (more than prempro) to completely slough the lining of your uterus - or you'll experience further spotting.
Prempro Side Effects [posted
Answer: Usually, the soreness persists for as long as you take the prempro. However, I can't figure any connection except that the Relafen is an antiinflammatory. Usually not real helpful in fibrocystic breast disease, but probably the answer with you.
Answer: In general, women stop having periods on prempro-- a major advantage according to most women. However, as long as there is hormonal stimulation of the uterus, there will tend to be occasional periods depending on the uterus and its lining. Occasionally, a D&C will stop the periods. Also, if they are very irregular an endometrial biopsy is usually suggested.
Answer: Prempro is the brand name for a combination drug containing conjugated estrogen and medroxyprogesterone acetate. This drug is used for treatment of post-menopausal estrogen replacement. The medroxyprogesterone is to limit the cancer risk of estrogen on the uterus. Side effects are a combination of both estrogen and progesterone side effects. These are weight gain, bloating, elevated blood pressure, breast tenderness, phlebitis, possible increase in gall stones, edema, etc. These are really very similar if not identical to anyone on birth control pills.
Answer: You cannot get prempro in the United States without a prescription.
Answer: Prempro is a brand name of a conjugated estrogen and medroxyprogesterone
product. It is mainly used to treat menopausal women with estrogen and progesterone
replacement. There are several ways to add estrogen to an estrogen deficient women. One
way is to give estrogen for about 21 days followed by a pulse of progesterone(or
equivalent). This produces a period and protects against uterine cancer. Another is to
give estrogen and progesterone on a daily basis - the rationale for Prempro. The side
effects are the same as for estrogen plus for progesterone. However, some advocate that
the balance between the two creates less overall risk of uterine and breast cancer.
Estrogen can elevate the blood pressure, cause phlebitis and increase the risk of blood
clots, inflame the breasts, and cause fluid retention. There are many books available in
the book store since this is a very hot topic. In general, I advocate estrogen replacement
for most women in the absence of specific contraindications.
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