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Doctors' Answers to "Frequently Asked Questions" - Oruvail


These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

Oruvail [posted 8/11/98]
Question: What side effects might I expect from this drug? I am taking it twice daily for joint inflammation. Should I avoid certain foods and/or alcohol while taking this?

Answer: Oruvail is a non-steroidal anti-inflammatory. In general, the side effects of this class of drug are GI. Diarrhea, nausea, gastritis, ulcers, etc. There is a long list of possible other problems but, 95% will be GI. Foods that increase gastric inflammation, alcohol, aspirin, etc. should be avoided.

Oruvail and Elevated Blood Pressure [posted 7/30/98]
Question: Can Oruvail cause an elevation in blood pressure? I am a diabetic, but I have taken Oruvail for about 4 months to treat an inflamed achilles tendon. Shortly after starting the Oruvail, my blood pressure, which has always been normal for my 52 years, increased to about 180/100. My regular physician prescribed Vasotec to treat the elevated blood pressure, and it now is in the 130/68 range. Tests have shown that there is no clogging of the arteries and the diagnosis is a constriction of the muscles surrounding the blood vessels, hence the Vasotec prescription. Is it just because I'm getting older, or might Oruvail have caused the increase in blood pressure?

Answer: Any of the non-steroidal anti-inflammatories can cause sodium retention and elevated blood pressure. This effect would cease within a few days after discontinuance of the drug. Occasional patients have decreased renal function on these drugs which could affect blood pressure as well, but is much less common.

Arthrotec and Oruvail
Question: What is the difference between Arthrotec & Oruvail. Is one better than the other? What are the side effects of these anti-inflammatory drugs?

Answer: Both are non-steroidal anti-inflammatories. They are from different classes and might have different effects in different people. But, from a practical point of view they usually work about the same with the same side effects (GI usually). Common side effects are gastritis, diarrhea, fluid retention, ulcers, decreased clotting ability.

Oruvail
Question: Do you have some information about adverse reactions to Oruvail? My wife is using Daypro and she feels depressed (I understand that is a side effect of the medicine), and I would like to know if the same will happen with Oruvail.

Answer: If your wife is depressed on DayPro, she will likely be depressed on Oruvail since they are from the same class of drugs. However, the only way to find out is to try it and see. DayPro and that class of drugs are not notorious for producing depression. I'd ensure that the DayPro is the culprit.

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