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Doctors' Answers to "Frequently Asked Questions" - Lotronix(Alosetron)
Answer: Alosetron(Lotrinex) is a inhibitor of the initial 5-HT3 mediated phase of the depolarizing response to 5-HT and it appears that alosetron prevents serotonin from binding to the 5-HT3 receptors. Alosetron increases colonic transit time(slows your bowel). It also, works better in women and although used in men, works much better in women. There are no current obvious drug interactions or effects on heart conduction times. Constipation is currently the only major side effect, but it has not been around long enough to know about long term effects.
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