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Doctors' Answers to "Frequently Asked Questions" - Estrace
Answer: The benefits of estrogen replacement are present in every area of your health except possibly in breast cancer. The best overall study was done on nurses over the last 20 years. About 5000 took estrogen and 5000 did not. The nurses taking estrogen had an average increase in longevity of 2-3 years as well as a significant improvement in quality(less strokes, more independent living, less pain and disability scores). Dementia was not scored, but there are several studies suggesting less dementia on estrogen. If any other drug did this, people would line up. I recommend estrogen highly unless there is a strong family history of breast cancer. The other potential risk is cancer of the uterus-the only proven risk by the way-and yours is surgically absent. I'd recommend the full dose in the absence of any other risks.
Vivelle vs. Estrace [posted 8/10/98]
Answer: In general, I am a strong advocate of estrogen replacement for women unless there is a strong history of cancer of the breast. The dermal estrogens probably have less liver toxicity. I would favor them - especially if you have had migraines with estrogen since the serum levels are touted as lower. There is a new drug coming out that is a "designer" estrogen. Expensive, but without the risk of breast cancer. What the effect will be on migraines and liver toxicity remains to be seen.
Switching from Premarin to Estrace [posted 7/23/98]
Answer: Well, hard to know. I have patients who clearly need one brand and many who don't seem to vary much with different brands or delivery systems. Can't tell you off hand why, but you'll need to see for yourself.
Estrace - Adverse Reactions to [posted 7/17/98]
Answer: Certainly would be uncommon/rare/unusual for estrace. The only way to tell is by stopping the drug. If the problem abates, restart the drug and see if it returns. If so discontinue the drug.
Answer: Estrace(estradiol) is basically an estrogen replacement drug. All estrogens are metabolized
through fat and other glandular tissue into testosterone. The testosterone is the hormone
responsible for hair loss. However, without the estrace base, the levels will be low. Many
women have hair loss in a "male pattern". This represents the loss of hair present on the genes
they inherited from their parents. Their male children will usually present with earlier hair
loss than average. Rogaine is usually very helpful in these women although it is expensive and
necessary on a lifetime basis. However, your hair loss will continue as long as you are on