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Doctors' Answers to "Frequently Asked Questions" - Eldepryl
Answer: Mao blockers will generally be "out" of ones system by 24-48 hours. This is the recommended time prior to surgery. In general, we use about one week in non-emergent situations to be absolutely sure of no generalized reactions. Consequently, after one stops a Mao inhibitor, most of the expected reactions will be gone in several days. I know ot no patches for delivery of eldepryl.
Answer: Eldepryl(selegilene hydrochloride) is a relatively new drug in the treatment of Parkinson's Disease. Eldepryl is an MAO inhibitor initially used in depression that has been found to be effective in treating Parkinson's. The mode of action is not completely understood, but seems to increase dopamine in the brain through its monoamine oxidase effect. MAO inhibitors can be potentiated by several types of food. Any food containing tyramine will cause problems. These include chicken liver, pickled herring, any cheese-aged are the most potent, yogurt, sour cream, beer, wine, canned figs, bananas, advocados, soy sauce, raisins, chocolate, many decongestants and weight loss agents, canned figs and broad beans(Fava,etc.). Ingestion of these substances can cause severe blood pressure excursions, rapid heart beats, and other side effects.
Answer: While Eldepryl does have an MAO type effect, the studies done in Parkinson's patients indicate that in the doses approved for Parkinson's Disease that it does not approach levels in the serum which are required to treat depression. I know of no ongoing trials concerning using this drug as an antidepressant. I would contact the company, Somerset Pharmaceuticals, Inc. for further information.
Eldepry Before Surgery
Answer: Eldepryl(selegiline hydrochloride) is a drug primarily used to treat Parkinson's Disease. It is a monoamine oxidase-Type B inhibitor. As such, certain drugs are a problem or a potential problem. These include serotonin reuptake inhibitor antidepressants, tricyclic antidepressants, and Demerol (meperidine). The manufacturer recommends a 14 day period between stopping Eldepryl and these drugs. Whether other opiates such as morphine cause this problem is less clear;however, most physicians assume that the interaction is possible.