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Doctors' Answers to "Frequently Asked Questions" - Depakote
Answer: Usually comes back.
Answer: There are reports of this, I do not have title and verse available. You can obtain this from the scientific department of Abbott 800-255-5162
Answer: I don't know of any interaction between Depakote and the thyroid. There is one sentence in the precautions of the PDR that notes that there are reports of changes in the thyroid test, but I have not seen this problem.
Answer: There arer potential toxicities. However, these can be monitored easily and there don't seem to be severe long term problems. Try the drug and see how it moderates your functional ability. The major problem is feeling drunk all the time. Neurontin would be less toxic and might be an answer depending on your EEG. But, the place you live is unlikely to have much bearing on the frequency of your seizures. Seizures are potentially life threatening, so need to be suppressed.
Answer: Wouldn't expect them to, but check the Depakote levels to ensure that they are not higher than usual.
Depakote for Schizophrenia Treatment [posted 10/15/98]
Answer: Depakote has been used in many different medical syndromes in the past couple of years based on its relatively unique activity. While it is not approved for the treatment of schizophrenia by the FDA, it has been used in treatment with mixed success.
Depakote & Herbal Pill [posted 10/13/98]
Answer: Neither is an mao inhibitor. There should be no problem with metabolife.
Depakote & Marijuana [posted 10/8/98]
Answer: Out of my league, but, I'd ask the company- Abbott 800-633-9110.
Depakote & Ephreda Use [posted 10/2/98]
Answer: None that I am aware of.
Liver Problems from Depakote [posted 7/23/98]
Answer: Depakote can cause liver toxicity in some patients for unclear reasons even if in the normal range. However, in general it is dose dependent. Aspirin does not appear to be a factor in this problem. As to the interaction between depakote and the statins, there is no clear evidence here, you'll need to monitor liver functions a little more closely.
Depakote Side Effects [posted 7/16/98]
Answer: Depakote has been used for a while, mainly for seizures, but also for other conditions. Side effects include headache, asthenia, decreased appetite, nausea, somnolence, body aches, vertigo, double vision, tremor, and hair loss. It depends a lot on the drug levels of the Depakote, but side effects are very common with this drug.
Depakote and Pregnancy [posted 7/16/98]
Answer: This study has not been done and will not be for ethical reasons. Studies in bacteria and mice haven't shown any particular worrisome effects.
Depakote and Effexor
Answer: Depakote has been implicated in causing discoid lupus. This would involve sun sensitivity. Otherwise neither is a big risk.
Answer: Depakote(divalproex sodium) is an anti-seizure drug which has been available about 10
years. Side effects include liver toxicity (some deaths, especially small children), low platelet
counts, nausea, sleepiness, vertigo, vomiting, abdominal pain, decreased appetite and rash.
These are the common side effects. The others have been listed
on rare occasions.
There is a low list of minor side effects available in the Physicians Desk Reference, which is available
in any book store or library.