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Doctors' Answers to "Frequently Asked Questions" - Translocated Chromosome

These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

Genetic Balanced Translocated Chromosome
Question: I am a carrier of a balanced translocated chromosome. I have had two children with a syndrome do to this balance. 1. Am I correct in my thinking that I probably will not have a normal child due to my chromosomes? I have had 2 children in a row with a syndrome. 2. Am I correct in thinking that all my eggs would have this balance translocation in the genetic make-up causing the syndrome? 3. Is it possible for me to have any eggs with a normal genetic make-up in them? 4. Would I have any hope of having a normal child naturally?

Answer: Without knowing the location and extent of the translocation its hard to say. In general, the balanced translocation will effect two chromosomes. If on complimentary chromosomes then this problem will always be transmitted. If on non-complimentary chromosomes then it will not. You need to discuss this with a genetic counselor to explain the long term risks. Depending on where this translocation is will determine the answers to your problem.

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