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Doctors' Answers to "Frequently Asked Questions" - Porphyria
Answer: I've never seen this used as a treatment for any of the porphyrias.
Answer: Known problem drugs are alcohol,barbituates,carbamazine,danazol,ergotamine preparations,synthetic estrogens and progesterones, glutethimide, griseofulvin, meprobamate, methylprylon, mephentoin, succinimides, and valproic acid.
Porphyria [posted 8/6/98]
Answer: Porphyria is an inherited disorder of hemo biosynthetic pathways. They are loosely classified into hepatic or erythropoietic. There are several different types: ALA dehydrase, acute intermittent porphyria, hereditary coproporphyria, varigate porphyria, porphyria cutanea tarda - these are hepatic. X-linked sideroblastic anemia, congenital erythopoietic porphyria, erythopoietic porphyria - are the erythropoietic types. Diagnosis can be difficult and needs to be done during a "crisis". Urine for coproporphyrins, ALA levels, and uroporphyrins are the usual tests. The difficult part is to suspect it in the first place and do the correct tests while the patient is having symptoms.
Antidepressants Use In Porphyria
Answer: I could find no information on any interaction of SRT anti-depressants and porphyria. Porphyria is an inherited disorder of metabolism due to overproduction or overaccumulation of porphyrin products. Porphyrins are ring structures generally used in blood synthesis. It is triggered by many drugs including sulfonamine antibiotics, alcohol, barbiturates, many seizure medications, griseofulvin, and ergotamine products. There are many subgroups of this disease depending on the defective enzyme or metabolic step.
Answer:Most of the porphyries produce pain and occasional confusion. I've never seen this particular paranoia. I'd check with some of the world experts Robert Desnick, MD Ph.D. Mt. Sinai Hospital New York is one.