Drug Infonet provides drug and disease information for your healthcare needs. Visit our FAQ page to find answers to common health questions. Look on the Manufacturer Info page to link to pharmaceutical company pages. Click to Health Info and Health News for the latest in healthcare developments.
Doctors' Answers to "Frequently Asked Questions" - Leukemia
Leukeran and Prednisone for Chronic Lymphocytic Leukemia [posted 7/22/98]
Answer: Leukeran (chlorambucil) is a drug used mainly in chemotherapy of different blood disorders. In small doses it is well tolerated and usually the first drug used in CLL. The dosage is usually increased until the counts drop and the smallest effective drug dosage used. Side effects would include nausea, diarrhea, low white counts, anemia and decreased bone marrow activity. Usually not see due to the small doses. Hypersensitivity reactions causing skin rashes and occasional neurologic symptoms are also seen. Prednisone is a steroid which long term has several side effects. It basically increases the aging process of many body systems. Thus, one can develop diabetes mellitus, osteoporosis, cataracts, muscle weakness, increased athlerosclerosis etc. This is also dose and duration dependent. That is the symptoms are higher with higher doses.