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Doctors' Answers to "Frequently Asked Questions" - Homocysteine
Answer: High homocysteine levels are usually thought to be an inherited phenomenon and not due to lipid lowering drugs. Smoking may also increase the levels according to some. Most would recommend fairly high dosages of B vitamins and folic acid to reduce the level, but it is not always effective.
Answer: You might try switching to Vioxx or Celebrex and see if your reflux improves. They will usually have less gi effects, but are more expensive. The others are common recommendations for patients in your situation and do not seem to have any interactional problems except liver toxicity. You should be getting liver function tests every 4-6 months. Having said that, the liver problem is uncommon. I assume they have rechecked your homocysteine and it is lower on the supplements? Most patients with elevated homocysteine need larger doses of B vitamins and folate to suppress it.
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