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Doctors' Answers to "Frequently Asked Questions" - Drug Interactions (Page
These comments are made for the purpose of discussion and should NOT be used as
recommendations for or against therapies or other treatments. An individual patient is
always advised to consult their own physician.
Interaction - Prozac and Valium [posted
Question: Doctor has prescribed a prescription for an elderly person 83 years of
age, who suffers from mild depression (I would assume natural for the age). In any case,
she has been given prozac 10 mg. She was doing very well, more upbeat, happy. A family
member who disperses the medication, does not feel that she should have to take it and
only gives it to her when he feels it is necessary. Instead he is giving her his valium,
and sometimes giving both at the same time. I have seen her shaky when she wakes up from
naps sometimes, and then she is automatically given the valium. I do not know much about
the interactions of both of the medications, but since valium is addicting I cannot
believe that it would be good for her to take. She is also on high blood medication and
Answer: Valium should be avoided, if possible, since it is a
depressant and poorly tolerated in the elderly. Prozac is not addicting and generally well
tolerated. The blood pressure and nitro patches probably have little interaction with
Many Drug Interactions [posted
Question: I would like to know the drug interactions for these drugs. They are
taken by my mother, and she seems to be suffering from more physical fatigue then she ever
1, 0.125 mg, Synthroid
2, 500 mg, Tylenol
1, 50 mg, Ultram
1, 10 mg, Zocor
1, 500 mg, Naproxen
1/2, 25 mg, Maxide
1, 550 mg, Naproxen Sodium 1, 50 mg, Ultram
1, 75 mg, Doxepin
2, 500 mg, Tylenol
Answer: No obvious interactions except somnolence and constipation.
Taking Wellbutrin and Prozac
Together [posted 1/14/99]
Question: I have been taking Wellbutrin and Prozac (a time released tablet and 20
mg of Prozac) in the mornings to help me deal with stress at work. Can you please tell me
of any concerns, side effects, etc. that I should be aware of?
Answer: Decreased sexual drive, dry mouth, constipation, occasional
Depakote with Serzone [posted
Question: My brother is being treated for bipolar disorder. He has seen two doctors
that have prescribed two different medications. One medication is Depakote, the other
Serzone. It seems that every possible side effect that can be caused by both medications
has hit my brother all at once and the poor man cannot physically get out of bed. Are
these medications safe to use together? I have read that Serzone should not be combined
with monoamine oxidasenhibitios. Does Depakote fall into this category?
Answer: Depakote is not an MAO drug, but an anti-seizure medication
used to treat a lot of other problems. Ensure his level has been checked.
Lipitor and Coumadin [posted
Question: I am currently taking Lipitor and would like to know if any drug
interactions between Lipitor and Coumadin (which I am also taking) have been reported.
Answer: No, but if you take both regularly, there won't be any problem
adjusting the dosage of coumadin. The problem with coumadin is intermittent interactions.
Daily interactions are easily treated.
Question: I would like information on possible interaction contraindications for
prednisone and synthroid taken for hypothyroidism. I have had pain/discomfort in my throat
for about 2 1/2 weeks, and my ENT diagnosed inflammation of the lingual tonsils. He did a
culture, but the results are not in yet. He prescribed a 2 week tapered schedule of
Prednisone for the inflammation. (I had a tonsillectomy when I was child). I am concerned
of the effect of prednisone in combination with the synthroid. I am a little reluctant to
take the prednisone. Isn't an antibiotic the better choice, assuming there is an
Answer: Well, there shouldn't be an interaction between the two. As to
the best treatment choice, antibiotics would be what most would use, but I haven't seen
Drug Interaction - Zestril
Triamterene/Hctz [posted 1/13/99]
Question: I take a daily dose of Zestril and Triamterene/Hctz for hypertension. Is
there any potential interaction problem with this drug combination?
Answer: Can elevate the potassium level. Most physicians would be very
careful or would avoid potassium sparing diuretics(the Triamterene part) with any ACE
inhibitor. However, if monitored closely would be ok.
Many Drug Interactions [posted
Question: I have been diagnosed with IBS. One doctor gave me lomotil, and another
gave me Bentyl. I currently take Lithium, Xanax, Doxepin, Thorazine and Tegretol. Will
these cause a problem with Bentyl?
Drug Interaction - Desimpramine
and DHEA [posted 1/13/99]
Question: I'm presently taking 100 mg of Desimpramine and 100 mg of Trazadone in
the evening to sleep. I want to know if there would be any obvious complications if I take
DHEA in 25 mg doses along with the other antidepressants I am taking?
Answer: There is no study of this possible interaction, you'll need to
try it. However, I doubt you'd see a problem.
Drug Interaction - Prozac and
Zyban [posted 1/13/99]
Question: What danger, if any, is there in taking Prozac and Zyban at the same
Answer: Excessive somnolence, constipation, etc. Should be monitored,
but probably won't be a problem.
Prozac and Ultram [posted
Question: I have been on Prozac 20 mg for 7 years or so and it is a wonder drug to
me. Recently I have been taking more naps. Could this be remedied with an increase in the
dose. In addition, I recently received Ultram for a foot injury. When I looked up the drug
both the Ultram and the Prozac had similar actions, however I hit a bottom of sadness that
can only be explained by some sort of clash with the two drugs. I thought going into the
treatment I would feel really good, but went crashing the other direction. Once I stopped
the Ultram and gave myself an extra dose of Prozac I was back to normal. Any thoughts?
Answer: Avoid ultram.
Interaction? - Lipitor and
Dilacor [posted 1/12/99]
Question: I take a combination of 20 mg of Lipitor (since 1997) and 180 mg of
Dilacor XR (since 1990), daily. Can this combination cause tiredness or lack of
enthusiasm? I've always been a rather lazy person, but lately I've noticed a deepening of
disinterest in just about everything.
Answer: It should have started as you started the drug, not later. I
would suspect something else.
Many Drug Interactions [posted
Question: My 72 year old mother is currently taking the below medications on a
daily basis. Please let us know if there are any potential adverse drug interactions.
Lanoxin - .125 mg once a day
Toprol XL - 50 mg three times a day
Coumadin - 2.5 mg two to three times a day
Vasotec - 10 mg two times a day
Zoloft - 100 mg once a day
Premarin - .625 mg once a day
Triam/HC - 37.5/25 once a day
(Chlorzoxazone - as needed)
Answer: Nothing big, the Toprol and the digoxin can both slow the
pulse and together can produce slow pulses in some patients. The diuretic triam/hc can
produce low potassium levels (although this one is less likely than most), which can
aggravate the digoxin. In general, shouldn't be a problem for most patients.
Glucophage and Rezulin [posted
Question: Should Glucophage And Rezulin be taken together, I heard someone say on
TV that Rezulin is good and Glucophage is good, but together they are better.
Answer: No problem taking them together and they do appear somewhat
Cardura and Vasotec [posted
Question: My dad recently had a heart attack. After quadruple by-pass surgery, his
doctor prescribed 10 mg Vasotec, 2 times a day. He was already taking Cardura once a day
(starts with 2 mg and dosage goes up to 4 mg). Should he be taking both of these drugs?
Answer: They are for different things. Both affect the blood pressure,
but in different ways. If his blood pressure is ok and he isn't having side effects there
is no reason not to combine these drugs. Cardura is often used in men to avoid prostate
surgery as well as bp control.
Drug Interaction -
Glipizide/Inderal [posted 1/5/99]
Question: Thank you for your generous contribution of time
and effort in your web site. The mysterious world of Latin names and medical mysticism can
be frightening to an ailing person and sometimes the doctors are less than communicative.
My wife, age 68, has been diagnosed (in August 1998) with early Diabetes. In reading it
seems she may have type 2 and the consensus seems to be the disease is so case sensitive
it is hard to regulate. She immediately entered a strict diet and has been very faithful
to it. She is trying to eat regularly and do the right things. She had taken Inderal for
twenty some years for irregular heart rate and though a couple of doctors she had over the
years wanted her to get off of it, none told her why. Attempts to switch her have result
in unhappy episodes and dropped. Her dosages through the years have ranged from 120 mg to
the current 20 mg. I just recently learned that Inderal is an insulin production inhibitor
(Beta blocker) and now this doctor who suspects early Diabetes has prescribed Glipizide,
which I learned stimulates the Beta cells to produce more insulin. Do we have a conflict
of interest here? She has had several bad bouts of fever, weakness, dizziness, depression,
and Panic. She has left the Glipizide and is trying to get off of Inderal so she can take
the Glipizide. The doctor gave her the medication and wants to see her in three months.
She has gotten a Glucometer and we determined a blood sugar count of not more than 150. At
least she can know when she needs extra sugar and when she might need the Glipizide, but
she is afraid to take it. Any help you could advise would be appreciated.
Answer: These medications can be taken together
without much risk. There is a theoretical blockage of insulin production, but in clinical
practice, it seems pretty small. There doesn't seem to be any risk combining the
medications in clinical practice. As long as you check the glucose with your home meter
and keep in touch with your doctor with the levels, you shouldn't have too much trouble.
Drug interactions/side effects[posted
Question: My doctor first put me on Zestril (20 mg once/day)
for hypertension. Subsequently, due to high triglycerides, he prescribed Lopid (600 mg
twice/day, as the generic Gemfibrozil). Subsequent to that, for high blood sugar (240,
fasting) I am taking Glyburide (2.5 mg once/day) and after 10 days my blood sugar was 211.
The dose has now been increased to 5 mg once/day. Could the ineffectiveness of the
Glyburide be due to some interaction with my other medications or is it due to an
unforeseen shortcoming of the generic medication? Also, for about the past two months I
have been experiencing a numbness in my big toes. The symptoms, while bilateral, are not
of equal severity in both feet, will vary during the day (less in the morning, most
noticeable in the evening) and will sometimes "flip" in the scope from left to
right or vice-versa. Any possibility of drug problems? I also supplement my diet with
selenium, chromium picolinate, and garlic tablets.
Answer: Doubt that it is due to the generic.
However, you may be developing diabetes that will need insulin versus oral agents. I doubt
the drugs would give the numbness, I'd check out your lower back.
Anitdepressants [posted 12/09/98]
Question: Is it safe to talke nsaids while taking antideppressants: elavil &
effexor & klonopin?
Buproprion & Prozac [posted
Question: Does buproprion cause depression? Any problems
taking prozac AND buproion? Have fibromyalgia also, any contrandictions? Feeling
absolutely awful, lethargic, no motivation, down, can't sleep. Any suggestions?
Answer: Not usually, these can be combined, but,
must be watched closely. Not commonly done, but probably ok. There shouldn't be any
specific problem with the fibromyalgia.
& Sodium Levels [posted 12/08/98]
Question: What affect do atorvastantin drugs have on serum
sodium, namely Zocor and Lipitor? My sodium has been dropping from 130mg in Aug. to 115mg
in Oct. (it was 140 in Dec.) Now its only 129mg. I am very concerned about my heart since
I've had a 95 percent and an 80 percent with stint blockages in heart, also recent
collapse and emergency room/hospitalization due to weakness and lightheadedness. Any help
would be appreciated.
Answer: Shouldn't be any, keep looking.
Buspar & Ambien [posted
Question: Can Buspar be safely taken with Ambien?
Answer: Yes, but, may result in a lot of sedation. I'd avoid the mix
Fluvastatin [posted 12/08/98]
Question: Please advise if Lescol fluvastatin has many side
affects and what they are.
Answer: Most are pretty minimal. It can affect liver function and this
should be monitored 2-4 times a year. It can cause muscle inflammation(1% or so of
patients) and a CPK should be checked at least once. Generally, very well tolerated with
minimal problems. Some patients will have mild gi complaints, nausea, diarrhea etc. Most
don't know they're taking the pill.
Provera [posted 12/04/98]
Question: When I started estrace and provera 5 years ago I
noticed stomach pains, gas and nausea. The gyn said it could be the hormones and suggested
an over the counter antacid. As the problems continued I sought help from a
gastroenterologist who eliminated ulcers and announced "gastritis".
Problems continued on and off, and then I was diagnosed in Nov. 1997 with Crohn's disease.
Ended up with small bowel resection Dec. 1998. Meanwhile, my stomach upsets
continue, apparently diff. from the Crohn's. And in keeping a log I notice that
almost exactly every 3 weeks I get so gassy and nauseous that I vomit for 1 to 7
hours. Then I am fine again. (I am also constipated, and prune juice seems to be helping).
Do you think the hormone replacement is the culprit, given the 3 week cycle? Thanks.
Answer: Sexual steroids have a profound effect on smooth muscle,
especially progesterone. Most women will experience a change in gi motility as their
progesterone levels rise, usually constipation. Lower doses of progesterone would probably
help. Also, start something a few days before the progesterone part of your hormones to
help with the constipation.
Antidepressants [posted 12/04/98]
Question: Does augmentin have any effect on antidepressants
given ie. decreasing effectiveness of antidepressants?
Multiple Medication Concerns [posted
Question: My 82 year old father is being treated for
migraines and REM S Sleep disorder with the following medications - Depakote 250 mg 3x
day, Florinef 1mg/day, Prilosec 20 mg./day, Synthroid .05 mg/day, Zyrtec, 10 mg/day,
Occuvite, Calcium, Aspirin 1/day At night he takes 1 mg Clonazepam for the REM Sleep
disorder. He is increasingly confused and still up several times a night and not sleeping
well. Several anti-depressants were also tried to relax him at night and he has severe
reactions to the combination. Are there any drug interactions possible with his list of
meds? Will Advil interact with any of the meds?
Answer: With patients of this age, I find that they are over medicated
more often than undermedicated. Stop everything you can and start over. Focus on drugs
like melatonin which will have minimal side effects. Ensure his sleep disorder is not his
prostate getting him up to urinate. Lastly, see a gerontologist if this doesn't work, this
is a lot of medications for an older man.
Prozac & Ibuprofen [posted
Question: Is it safe to take Ibuprofen with Prozac at the same time?, because I did
that last night and I was having problems with my breathing.
Answer: Shouldn't be a problem.
Procardia, Prevacid, &
Premarin Concerns [posted 12/02/98]
Question: I am on Procardia XL 30mg, Prevacid 30mg, and
Premarin 1.25mg. I am 42 years old. What can I expect in my future as far as health
related problems from these drugs. Can they interact?
Answer: Shouldn't be any particular interaction
problem over time that you don't see in the short term. Long term risks of Premarin are
cancer of the uterus and possibly breast. The other two don't have any currently
identified long term risks.
Percodan & Zyprexa
Question: My grandmother has been taking percodan for two weeks for pain for her
back. She also is taking zyprexa and is becoming very disoriented- I am very concerned
about this. Do these two drugs counteract each other? Are they harmful together?
Answer: No, but both can cause disorientation especially in the
elderly. I suspect she is getting drug toxic.
& Accupril [posted 12/1/98]
Question: Recently my doctor has added Accupril to my daily medication. I had five
coronary rafts almost two years ago and have been taking Toprol since then. I think it was
to lower my BP and to help the work load on my heart. Since I've been taking Accupril in
addition to the Toprol(about a month) I've had occasional slight angina attacks in my
lower throat area. I've also had a sore throat, and I've been lightheaded occasionally. Is
there another drug to supplement the Toprol that would be less likely to cause these
Answer: Either less milligrams of the Accupril or an Angiotensin
Blocker like Cozaar.
Drugs & Tendon Problems [posted 11/25/98]
Question: I have been taking Lipitor, 20 Mg daily for over a year and a half with
no noticeable side effects. My total cholesterol was lowered from around 280 to 180. The
blood tests did not indicate any elevated levels from the liver panel test. The last blood
test I had was about 1 year ago. I recently tore my achilles tendon playing indoor soccer
and have had surgery to repair this. My surgeon asked me again today if I have been taking
cholesterol lowering drugs, and commented that lately several of his patients with torn
achilles or other tendons were also taking either Lipitor or other Cholesterol lowering
drugs. He did not know of any connection, but was going to look into the possible
connection. Have there been any studies to determine if Cholesterol lowering drugs cause
any weakening of the tendons?
Answer: Not to my knowledge.
& Viagra [posted 11/25/98]
Question: If a man is taking 70 mg.of Methadone,(liquid a day) should he be
taking Viagra 25mg.? If a man is taking Albudural pills and Dilanten should he be taking
Viagra? Thank-you for any answers you may be able to give me.
Answer: There is no clear drug interaction data available on Viagra
currently. However, drugs which dilate the circulation (nitroglycerin) appear to have
potential interactions on blood pressure in these patients.
& Trazadone [posted 11/24/98]
Question: I am taking 1000 MG of relafen (for arthritic knees) amd 25 MG of
trazadone (for fibromyalgia) per day. Is it possible that either of/or the combination of
these two drugs can be causing stomach cramps and diarrea?
Answer: Pretty common with all the nsaids (relafen belongs to this
While on Depakote & Imipramine [posted 11/24/98]
Question: I'm wondering if taking Phentermine, while on
Depakote & Imipramine for Migraines, is safe?
Answer: Hard to know. The combination of
fenfluramine with phenteramine was a potential problem. Whether the phenteramine is by
itself is unclear. There is no data on the combination of Depakoe and Imipramine.
Any Concerns Regarding Taking
Synthroid & Coumadin [posted 11/24/98]
Question: If my 69 year old mother in law leaves the hospital after her bypass
surgery and TIA stroke, with a prescription for coumadin, will there be any interaction
with the synthroid medication she takes for hypothyroidism?
Mixing Metabolife 356 with St.
John's Wort & Fiornol [posted 11/19/98]
Question: I am beginning to start a Metabolife 356 program. I currently taking St.
John's Wort. I was told that is a Mao Inhibitor and I should not take these two together.
I am worried about the effects on my body. Could you please let me know what the effects
can be and if this is dangerous? One of the ingredients in the Metabolife 356 id Ma Huang
Concentrate, this is a naturally occuring ephedrines. Could you please explain what that
is in english? What effects do ephedrines have on your body? Should I not be mixing these
two together? I also take Fiornol for migraines, is this not to be mixed? I really
appreciate your prompt response, thank you.
Answer: Do not mix these two. You may have few side effects;but,
you are potentially risking a major hypertensive crisis with the combo. Fiornial should be
Cefaclor with Asthma Medications
Question: My doctor prescribed Cefaclor (250mg) for a sinus infection. What, if
any, side-effects are related to this drug? Also, suffer from chronic Asthma so naturally
I'm concerned with taking a new drug that may interact with the Asthma medications I am
currently taking which are: Accolate, Meprobamate, Claritin-D, breathing treatments three
times daily, an allergy shot once weekly, inhalers Serevent, Flovent and Combivent.
Answer: Usually diarrhea, possible allergies etc. Nothing any
different from the others-except more expensive.
St. John's Wort with Metoprolol [posted
Question: I have been taking 50mg of Metoprolol a day for years for tachychardia.
Would there be anything dangerous about taking St. John's Wort with Metoprolol? Sometimes
I feel tired, or depressed, and I heard those are side effects of Metoprolol. Thanks.
Answer: Probably not, St. Johns is a mild MAO inhibitor which should
be tolerated with beta blockers. However, get a list of foods from your md to avoid on mao
inhibitors. These in conjunction with St. Johns wort could cause tachycardia. This is
theorectical and I haven't seen it in practice, still something to be aware of.
Multiple Medications for Pain
Management [posted 11/18/98]
Question: I take the following medications for pain management of severe congenital
scoliosis ... nortriptyline (80mg) & Relafen (1500mg). I take Premarin/Provera for
HRT. I use a provental inhaler for exercise induced asthma. My asthma is no-longer
exercise induced. I lost lung capacity from scoliosis surgery performed last fall which
fused C6-L2 anterior and posterior. The pulmonologist started me on Singulair and
Azmacort. This is working OK, except the insurance is refusing to cover Singulair, but
will cover Accolate although neither Singulair or Accolate are on their formulary. Both
Relafen and Accolate have cautions about metabolizing in the liver. Accolate has
additional cautions about tri-cyclic anti-depressants. Do you think that introducing
Accolate in place of Singulair will create risks that I wouldn't have if I was taking
Singulair instead of Accolate? Thank you.
Answer: Actually, Singular probably has somewhat more liver
problems than Accolate. Both should have liver functions checked regularly and you should
also get levels of nortriptyline until everything is balanced. However, probably not a big
deal as long as your doctor is familiar with these drugs and keeps an eye on things.
Dapro & Claritin with
Chlortrimeton [posted 11/18/98]
Question: Can chlortrimeton be taken with Dapro 600mg and/or Claritan?
Answer: Not with Claritin, Dapro is ok.
Question: I have been taking the above three medications for over a year. I think I
have gained about 20 pounds in the last 3 years or so. Could any of these cause the weight
gain? I have always been a small female but now I am about 140 pounds at 5'2". I have
heard that taking the "pill" always puts on about 10 pounds, but I am unsure of
the rumor. Please also advise on long term use on all three drugs. Thank you for your
Answer: SRI drugs cause weight gain in about 40% of my patients.
Depakote and Zyprexa [posted
Question: My mother has been on depakote and zyprexa for over 45 days and now has
mysterious swelling in hands and feet, and a fever over 104. The regular dr. said just
some new virus and did not run a test one just gave us another pill...Should I be
concerned.? I have fever under control, but hands and feet stay etreemly swollen and
painfull for her.
Answer: Hard to know, but, if it persists not a virus and you should consider a
drug reaction first. There is a medical condition with elevated temperature and drugs like
Pravachol & Doxycycline
Question: My doctor has put me on pravachol. Im also taking doxycycline do these
drugs interact ok?
Answer:Shouldn't be a problem.
Multiple Medications & Fatigue [posted
Question: My mother, age65 currently takes the following prescriptions: for
depression and anxiety: loreazepam 3 mg/day, imipramine 100 mg/day,metoprolol 50 mg/day,
prozac 10mg/day, synthroid .1mg/day. For recent hip replacement surgery: darvocet as
needed (not on a regular schedule), and for cholesterol: zocor 40 mg/day. Currently
experiencing fatigue and memory loss. Can you advise as to interaction problems and side
Answer: She is taking 4 different drugs that can cause fatigue and/or mental
confusion. Lorazepam, imipramine, prozac and darvocet. They tend to be additive in terms
of the above problems with prozac probably being the least problem. She should discuss
decreasing the dosage with her physician. Metaprolol is notorious for causing fatigue
without mental status changes. She looks overmedicated .
Vitamins & Tri-cyclin [posted
Question: Im on tricyclen and want to know if there are any problems with taking
vitamins B6, B12, B1 Biotin , Riboflavin, Inositol, or L-Carntine with it. I've looked all
over and cant find the answer. thanks! Also are there any reasons I should think of not
taking any of these vitamins.
Answer: No clear problem.
THC & Antidepressants [posted
Question: I would like some information on drug interaction between THC and
antidepressents(serzone),if you would be so kind.
Answer: I don't have specific information. I would check with Bristol Myers
Squibb's medical research department 800-321-1335. They usually have this type of
Coumadin, Luvox, Klonopin [posted
Question: I first want to say that I find your site extremely helpful. I've been
scouring the web for the past two hours, searching for resources that can answer my
mother's distress, and I find the opportunity to interact with someone about this most
encouraging. My mother has been on coumadin for the past month, and, because she also has
an extreme case of OCD and depression, she is literally going nuts. I think, also, since
she has been taken off her estrogen patch (she received three surgeries last fall--a
hysterectomy and two hernia operations), she is not in the best of moods. She says she can
barely get out of bed, and the slightest hit results in bleeding. The other day, she cut
her toenails and subsequently bled for three days--the doctor told her not to wash her
feet, and she lives in a Southern rural town! She continuously complains of feeling weird,
as if her body is gradually shutting down. Can she be suffering from drug interactions?
Her doctor says that there shouldn't be a problem with taking coumadin, luvox and
klonopin--yet, in my recent research, I saw that there is a high clinical possibility for
interaction between luvox and warfarin. Her recent INR stats have been 1.5 and 1.325--and
she's been on the drug for a little more than a month. She feels a lump in her right leg
(where she had three huge clots and several smaller ones), and the doctor says she could
not have any clots. Her protime is about 25. I'm trying to find solutions so that she can
get back on the great progress track she was on. Thank you for any advice you can give.
Answer: The interaction of these drugs would be to change the metabolism of
coumadin by the liver;but, this is measured by the INR, so as long as your md watches that
there shouldn't be bleeding. One can still get clots on coumadin, less likely as the INR
rises-but, still possible. I would try returning the estrogen although there is a distinct
risk of further clotting and see if her mental status improves. Risky and needs close
supervision;but, sounds like she is obsessing with the coumadin.
Cortisione Use for person with
Bipolar Disorder [posted 11/5/98]
Question: What effect would cortisone have on someone who is a manic depressive?
Answer: Depends on the dosage and the method of delivery. In general, very
Could a Facial Skin Discoloration be
Due to Drug Interaction [posted 11/4/98]
Question: I am on multiple medications. Recently, I have been taking Pamelor(for
the past month). I also take regularly: inderal, periactin, dilantin, premarin (post
hysterectomy), neurotin, synthroid,robaxin,daypro,darvocet(for past 2 months due to car
accident). My facial skin has begun to discolor recently. It is turning brown in areas. I
do not go in the sun at all, and have never had this problem before.
Answer: Premarin or dilantin would be the first drugs to check.
Ultram & Zoloft [posted
Question: I would like to know more about the ultram's half life being extended by
the zoloft (due to its acting upon the enzyme in the liver that breaks metabolizes the
ultram). Can zoloft intensify or prolong the presence and or effect of the ultram? What
are the suggestions for recognizing and stopping the physical addiction? Does the same
type of problems exist with tylenol/codeine#3 and zoloft? I'm a medical assistant and a
Graduate student in Marriage and Family Therapy; so if you could point me to some journal
articles and other medical research, it would be very welcome. Still, even the simplest
response if it has the info I need is great... and very welcome.
Answer: I'm unaware of the Zoloft /Ultram interaction, I would check with the
scientific dept of Ortho-McNeil(makers of ultram) 800-682-6532, they are usually very
helpful. I know of no interaction between zoloft and Tyl # 3. As to the addiction
potential, it is hard to recognize with Ultram. It tends to be similar to regular narcotic
addiction in terms of wierd feelings, nausea and some gi symptoms on withdrawal.
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