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Doctors' Answers to "Frequently Asked Questions" - Chromosomes

These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician.

Balanced Translocated chromosomes [posted 1/12/99]
Question: I have this condition. I have had 9 pregnancies. I have 3 boys and 1 girl. One of my boys has the balanced translocation, the other two I don't know about. My daughter has perfectly balanced chromosomes. My translocation is on the 5th and 17th. My karyotype is 46,xx,t(5;17) (q34;p13.3). When I have become pregnant out of my right ovary, I have miscarried and when it has been out of my left I have had a normal baby, so do you think the eggs in my right side are defected in some way? (I know which side the egg came from because I have had early ultrasounds and the doctor was able to tell). My brother also has the same karyotype with the balanced Translocation. Are men more likely not to pass this condition on because of the number of sperm they have? Since my brother and I both have this condition, one of our parents must have passed it to us and my mother never miscarried, so I would guess it is my father who has the condition. (My mother had 5 children).

Answer: You need to see a genetic counselor and have your whole family evaluated. However, the side of the ovary probably has little effect. It could be either your father or mother, the miscarriage has to do with the viability of the fetus, not a predictor of the genetic contributor.

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