Thrombocytopenia
Question: Can you tell me what Thrombocytopenia is and how it is caused? Also, can you tell me what happens if you get a severe or minor bruise or cut and you have to desise?

Answer: Thrombocytopenia is a low platelet count. Platelets are produced by the bone marrow and usually run 150,000 to 300,000. A low count is usually under 100,000, although some use 50,000. There are many causes of low platelets. There are many diseases which cause the problem. I'd refer you to Harrison' s Principles and Practices of Medicine(available in most libraries) for a more detailed list. The causes range from diseases like lupus to drugs, to viral infections to Idiopathic(unknown) causes. Many blood disorders will cause this problem also.

Thrombosis
Question: I come from a big family. My father has had deep vein thrombosis several times. He is an active man. One time it was the result of surgery and he survived. However, my 26 year old sister died from a saddle embolism very unexpectedly. She was somewhat overweight and took the birth control pill. I also had an aunt who died of a pulmonary embolism as well. Is there a some kind of genetic flaw in our family? What can I do to assure myself that this will not happen to me or anyone else in my family again. What type of test should I have done if you recommend that route?

Answer: There are several inherited causes of thrombosis and you certainly have a family history that could be affected. Tests need to be done by your internist to check Protein C, Protein S, Antithrombin III, homocysteinuria, and lupus anticoagulants. Those are the current deficiencies that could result in excess clotting. If you do not have the problem, others in your family should be checked.
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